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Zolpidem, sold under the brand name Ambien, among others, is a medication primarily used for the short-term treatment of sleeping problems.^[7][8] Guidelines recommend that it be used only after cognitive behavioral therapy for insomnia and behavioral changes, such as sleep hygiene, have been tried.^[9][10][11] It decreases the time to sleep onset by about fifteen minutes and at larger doses helps people stay asleep longer.^[5] It is taken by mouth and is available in conventional tablets, sublingual tablets, or oral spray.^[7]buy ambien online

Common side effects include daytime sleepiness, headache, nausea, and diarrhea.^[7] Other side effects include memory problems, hallucinations, and substance abuse.^[5] The previously recommended dose was decreased in 2013, by the US Food and Drug Administration (FDA), to the immediate-release 10 mg for men, and 5 mg for women, in an attempt to reduce next-day somnolence.^[12] Newer extended-release formulations include the 6.25 mg for women, and 12.5 mg or 6.25 mg for men, which also cause next-day somnolence when used in higher doses.^{[medical citation needed]} Additionally, driving the next morning is not recommended with either higher doses or the long-acting formulation.^[12] While flumazenil, a GABA_A–receptor antagonist, can reverse zolpidem’s effects, usually supportive care is all that is recommended in overdose.^{[13] buy ambien online}

Zolpidem is a nonbenzodiazepine Z drug which acts as a sedative and hypnotic.^[7][14] Zolpidem is a GABA_A receptor agonist of the imidazopyridine class.^[7] It works by increasing GABA effects in the central nervous system by binding to GABA_A receptors at the same location as benzodiazepines.^[7] It generally has a half-life of two to three hours.^[7] This, however, is increased in those with liver problems. ^{buy ambien online}

Zolpidem was approved for medical use in the United States in 1992.^[7][15] It became available as a generic medication in 2007.^[16] Zolpidem is a Schedule IV controlled substance under the Controlled Substances Act of 1970 (CSA).^[5][6] More than ten million prescriptions are filled a year in the United States, making it one of the most commonly used treatments for sleeping problems.^[17][18] In 2018, it was the 60th most commonly prescribed medication in the United States, with more than 12 million prescriptions.^[19][20]